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Association of capsular polysaccharide locus 2 with prognosis of Acinetobacter baumannii bacteraemia
- Source :
- Emerging Microbes and Infections, Vol 11, Iss 1, Pp 83-90 (2022)
- Publication Year :
- 2022
- Publisher :
- Taylor & Francis Group, 2022.
-
Abstract
- Acinetobacter baumannii causes healthcare-associated infections worldwide. Capsular polysaccharide (CPS) is shown an important virulence factor of A. baumannii both in vitro and in vivo. Capsule locus 2 (KL2) for CPS is the most common KL type and is associated with carbapenem resistance. It is unclear whether KL2 is related to the clinical outcome of invasive A. baumannii infection. Here we had followed patients with A. baumannii bacteraemia prospectively between 2009 and 2014. One-third of the unduplicated blood isolates were randomly selected each year for microbiological and clinical studies. The KL2 gene cluster was identified using polymerase chain reaction. A total of 148 patients were enrolled randomly. Eighteen isolates (12.2%) carried KL2, and 130 isolates (87.8%) didn't. Compared with non-KL2 isolates, KL2 isolates had significantly higher resistance to imipenem, sulbactam, and tigecycline. Compared with the non-KL group, in the KL2 group, the hospital stay before development of bacteraemia was longer (P
- Subjects :
- medicine.medical_specialty
Imipenem
Epidemiology
Immunology
Tigecycline
Infectious and parasitic diseases
RC109-216
Microbiology
Virology
White blood cell
Internal medicine
Drug Discovery
medicine
capsule locus 2
biology
business.industry
Hazard ratio
General Medicine
Sulbactam
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Confidence interval
capsular polysaccharide
QR1-502
Acinetobacter baumannii
virulence
Pneumonia
Infectious Diseases
medicine.anatomical_structure
outcome
Parasitology
business
acinetobacter baumannii
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 22221751
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Emerging Microbes and Infections
- Accession number :
- edsair.doi.dedup.....3b9e5d0f8f38676744f3c03c57bddb9b