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Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma
- Source :
- Graefe's Archive for Clinical and Experimental Ophthalmology
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Purpose To improve structure-function analysis in primary open-angle glaucoma (POAG) by including the two-global flash multifocal electroretinogram (2F–mfERG) and macular ganglion cell layer segmentation. Methods Twenty-five glaucoma patients (six pre-perimetric (PPG), 19 POAG) and 16 controls underwent 2F–mfERG, optical coherence tomography (OCT), and standard automated perimetry (SAP). For 2F–mfERG, the root mean square was calculated for the focal flash response at 15–45 ms (DC) and the global flash responses at 45–75 ms (IC1) and 75–105 ms (IC2). For OCT, macular total thickness (mT) and ganglion cell-inner plexiform layer (GCIPL) thickness were analysed. Values from the central 10° and 15° of 2F-mfERG were compared to the corresponding areas from OCT and visual field. Results Both PPG and POAG had significantly lower mfERG responses in the central 10° and 15° than the control group. Of the glaucoma patients, 30.7% (three PPG, five POAG) showed central mfERG and GCIPL reduction without a SAP defect in the central 15 degrees. Four patients had a central SAP defect associated with a reduced GCIPL without any detectable dysfunction on mfERG. MfERG DC and IC2 were larger with increased mT (p ≤ 0.02), but GCIPL only related positively to IC2 (p = 0.027). SAP sensitivity also increased with thicker mT but not with GCIPL (p
- Subjects :
- Male
Ganglion cell
medicine.medical_specialty
Time Factors
genetic structures
Glaucoma
Retina
Standard automated perimetry
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Optics
Optical coherence tomography
Ophthalmology
Electroretinography
medicine
Humans
Ganglion cell layer
Intraocular Pressure
medicine.diagnostic_test
business.industry
Automated perimetry
Structure function
Early glaucoma
Middle Aged
medicine.disease
eye diseases
Sensory Systems
Ganglion
Visual field
medicine.anatomical_structure
030221 ophthalmology & optometry
Female
sense organs
Visual Fields
Multifocal electroretinogram
business
Glaucoma, Open-Angle
Photic Stimulation
Tomography, Optical Coherence
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1435702X and 0721832X
- Volume :
- 255
- Database :
- OpenAIRE
- Journal :
- Graefe's Archive for Clinical and Experimental Ophthalmology
- Accession number :
- edsair.doi.dedup.....3b9294764fbf575e7be6f1de827ddae0