Assessment of micronuclei induction in peripheral erythrocytes of fish exposed to xenobiotics under controlled conditions

Biomarkers of exposure & effect:: validationBiomarker: MNExposure/effect represented: genetic damageStudy type (in vitro, animals, humans): fishMode of exposure (if in vivo) (acute, chronic, root of exposure):chronicTissue/biological material/sample size:4*103 erythrocytes/animalMethod of analysis: MN testSensitivity (LOD): low baseline frequencyIntra-individual variation: large range of variabilityInter-individual variation:0-2 MN frequencyDose-response: 2.95 MN/1000 cells compared to 1MN/1000 cells in the control, p