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Individual Differences in Opioid Efficacy for Chronic Noncancer Pain
- Source :
- The Clinical Journal of Pain. 24:509-520
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- Objective: Over a decade ago, Jamison noted the lack of studies that identify patient profiles or specific groups that might be best suited for opioid treatment of chronic noncancer pain. Methods: This paper reviews the studies that provide evidence for individual differences in opioid analgesia for chronic noncancer pain. Results: What we have found is that few investigations have addressed these important aspects of pain treatment. The most consistent finding is that depression and anxiety are associated with increased risk for drug abuse and decreased opioid efficacy. Discussion: The question remains whether the psychologic disorders antedated the pain condition or whether the experience of chronic pain exerts psychologic pressures that cause changes in behavior and psychologic processes. Additionally, the overall pattern suggests that younger age is predictive of opioid abuse and greater opioid efficacy. We also present a brief review of biologic mechanisms that support individual differences on opioid analgesia.
- Subjects :
- medicine.medical_specialty
business.industry
Analgesic
Age Factors
Individuality
Chronic pain
Pain
medicine.disease
Analgesics, Opioid
Substance abuse
Anesthesiology and Pain Medicine
Nociception
Opioid
Chronic Disease
medicine
Humans
Anxiety
Neurology (clinical)
medicine.symptom
Psychiatry
Adverse effect
business
Depression (differential diagnoses)
Clinical psychology
medicine.drug
Subjects
Details
- ISSN :
- 07498047
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- The Clinical Journal of Pain
- Accession number :
- edsair.doi.dedup.....3b8b560f48550509081510e5a1c488a8