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Small, dense HDL3 particles attenuates apoptosis in endothelial cells: Pivotal role of apolipoprotein A-I
- Source :
- Journal of Cellular and Molecular Medicine, Journal of Cellular and Molecular Medicine, 2009, 14 (3), pp.608-620 ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, 14 (3), pp.608-620 ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, 2009, ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, 14 (3), pp.608-620 〈10.1111/j.1582-4934.2009.00713.x〉
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; Abstract Plasma high-density lipoprotein (HDL) protect endothelial cells against apoptosis induced by oxidatively modified low-density lipoprotein (oxLDL). The specific component(s) of HDL implicated in such cytoprotection remain(s) to be identified. Human microvascular endothelial cells (HMEC-1) were incubated with mildly oxLDL in the presence or absence of each of five physicochemically-distinct HDL subpopulations fractionated from normolipidemic human plasma (n=7) by isopycnic density gradient ultracentrifugation. All HDL subfractions protected HMEC-1 against oxLDL-induced primary apoptosis as revealed by nucleic acid staining, annexin V binding, quantitative DNA fragmentation, inhibition of caspase-3 activity, and reduction of cytoplasmic release of cytochrome c and apoptosis-inducing factor. Small, dense HDL3c displayed twofold superior intrinsic cytoprotective activity (as determined by mitochondrial dehydrogenase activity) relative to large, light HDL2b on a per particle basis (p
- Subjects :
- Apolipoprotein B
[SDV]Life Sciences [q-bio]
Immunoblotting
anti-oxidative activity
Apoptosis
030204 cardiovascular system & hematology
Cell Line
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sphingosine
Annexin
Humans
HDL particle heterogeneity
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
reactive oxygen species
0303 health sciences
Apolipoprotein A-I
biology
Caspase 3
Cholesterol
Cytochrome c
Cytochromes c
Endothelial Cells
nutritional and metabolic diseases
Lipoproteins, HDL3
Articles
Cell Biology
Cytoprotection
Molecular biology
Cell biology
Lipoproteins, LDL
chemistry
[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
anti-apoptotic activity
sphingosine-1-phosphate
biology.protein
Molecular Medicine
Density gradient ultracentrifugation
lipids (amino acids, peptides, and proteins)
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Lysophospholipids
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
BH3 Interacting Domain Death Agonist Protein
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 15821838 and 15824934
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine, Journal of Cellular and Molecular Medicine, 2009, 14 (3), pp.608-620 ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, 14 (3), pp.608-620 ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, 2009, ⟨10.1111/j.1582-4934.2009.00713.x⟩, Journal of Cellular and Molecular Medicine, Wiley Open Access, 2009, 14 (3), pp.608-620 〈10.1111/j.1582-4934.2009.00713.x〉
- Accession number :
- edsair.doi.dedup.....3b83148b219329d2213f04cdccd5f1ce