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Development and External Validation of a Nomogram for Predicting Overall Survival in Stomach Cancer: A Population-Based Study
- Source :
- Journal of Healthcare Engineering, Journal of Healthcare Engineering, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- Objective. The study was to develop and externally validate a prognostic nomogram to effectively predict the overall survival of patients with stomach cancer. Methods. Demographic and clinical variables of patients with stomach cancer in the Surveillance, Epidemiology, and End Results (SEER) database from 2007–2016 were retrospectively collected. Patients were then divided into the Training Group (n = 4,456) for model development and the Testing Group (n = 4,541) for external validation. Univariate and multivariate Cox regressions were used to explore prognostic factors. The concordance index (C-index) and the Kolmogorov–Smirnov (KS) value were used to measure the discrimination, and the calibration curve was used to assess the calibration of the nomogram. Results. Prognostic factors including age, race, marital status, TNM stage, surgery, chemotherapy, grade, and the number of regional nodes positive were used to construct a nomogram. The C-index was 0.790 and the KS value was 0.45 for the Training Group, and the C-index was 0.789 for the Testing Group, all suggesting the good performance of the nomogram. Conclusion. We have developed an effective nomogram with ten easily acquired prognostic factors. The nomogram could accurately predict the overall survival of patients with stomach cancer and performed well on external validation, which would help improve the individualized survival prediction and decision-making, thereby improving the outcome and survival of stomach cancer.
- Subjects :
- Oncology
Multivariate statistics
medicine.medical_specialty
Medicine (General)
Article Subject
genetic structures
Biomedical Engineering
Health Informatics
R5-920
Stomach Neoplasms
Internal medicine
Epidemiology
medicine
Overall survival
Medical technology
Humans
Stage (cooking)
R855-855.5
Stomach cancer
Neoplasm Staging
Retrospective Studies
business.industry
External validation
Univariate
Nomogram
medicine.disease
Nomograms
Surgery
business
Biotechnology
Research Article
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 20402309 and 20402295
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Journal of Healthcare Engineering
- Accession number :
- edsair.doi.dedup.....3b71649976bb2091634e2e5129e7c2f3