Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock

Authors :: Solenn Remy
Etienne Javouhey
Guillaume Monneret
Jack Hayman
Aurélie Portefaix
Fabienne Venet
Alexandre Belot
Morgane Gossez
Hospices Civils de Lyon, Paediatric Intensive Care Unit
Mother and Children University Hospital
Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques - EA 7426 (PI3)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon
Rheumatism and autoimmune diseases (RAISE)
Hospices Civils de Lyon, Immunology Laboratory
E. Herriot Hospital
EPICIME-CIC 1407 de Lyon
Inserm, Service de Pharmacologie Clinique, CHU-Lyon
Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405)
Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)
Source :: Critical Care, Critical Care, BioMed Central, 2018, 22 (213), 2 p. ⟨10.1186/s13054-018-2146-2⟩, Critical Care, Vol 22, Iss 1, Pp 1-2 (2018)
Publication Year :: 2018
Publisher :: HAL CCSD, 2018.
Abstract: Clinical presentations of hemophagocytic lymphohistiocytosis (HLH) and septic shock share many similarities, including multiple organ dysfunction and overall clinical and biological symptoms. However, these life-threatening conditions require specific and opposing treatments. Currently, no single biomarker is available to differentiate septic shock from HLH at patient admission

Language :: English
ISSN :: 13648535 and 1466609X
Database :: OpenAIRE
Journal :: Critical Care, Critical Care, BioMed Central, 2018, 22 (213), 2 p. ⟨10.1186/s13054-018-2146-2⟩, Critical Care, Vol 22, Iss 1, Pp 1-2 (2018)
Accession number :: edsair.doi.dedup.....3b6d6f25f84100c612a53ff2e1cd8b93
Full Text :: https://doi.org/10.1186/s13054-018-2146-2⟩

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