Back to Search
Start Over
Moenomycin analogues with modified lipid side chains from indium-mediated Barbier-type reactions
- Source :
- Vogel, S, K., S, L., H, M., F, S., G, P., W & M., L 2001, ' Moenomycin analogues with modified lipid side chains from indium-mediated Barbier-type reactions. ', Tetrahedron, vol. 57, no. 19, pp. 4139-4146 ., University of Southern Denmark
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- From moenomycin A both the chromophore part and the lipid side chain were degraded by ozonolysis to give an analogue with a glycolaldehyde unit in 2-position of the glyceric acid moiety. The aldehyde was converted to a number of homoallylic alcohols by indium-mediated Barbier-type reactions with allylic and benzylic halides. With exception of the phytyl bromide-derived reaction product all compounds were antibiotically inactive.
Details
- ISSN :
- 00404020
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi.dedup.....3b6aa04c2d8e3868f6ffdd6fd0599acb