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SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma
- Source :
- Laboratory investigation; a journal of technical methods and pathology. 101(2)
- Publication Year :
- 2020
-
Abstract
- The overexpression of glutathione peroxidase 4 (GPX4; an enzyme that suppresses peroxidation of membrane phospholipids) is considered a poor prognostic predictor of diffuse large B-cell lymphoma (DLBCL). However, the mechanisms employed in GPX4 overexpression remain unknown. GPX4 is translated as a complete protein upon the binding of SECISBP2 to the selenocysteine insertion sequence (SECIS) on the 3′UTR of GPX4 mRNA. In this study, we investigated the expression of SECISBP2 and its subsequent regulation of GPX4 and TXNRD1 in DLBCL patients. Moreover, we determined the significance of the expression of these selenoproteins in vitro using MD901 and Raji cells. SECISBP2 was positive in 45.5% (75/165 cases) of DLBCL samples. The SECISBP2-positive group was associated with low overall survival (OS) as compared to the SECISBP2-negative group (P = 0.006). Similarly, the SECISBP2 and GPX4 or TXNRD1 double-positive groups (P
- Subjects :
- Male
Programmed cell death
Thioredoxin Reductase 1
GPX4
medicine.disease_cause
Pathology and Forensic Medicine
Gene Knockout Techniques
Downregulation and upregulation
hemic and lymphatic diseases
Cell Line, Tumor
medicine
Humans
Selenoproteins
Molecular Biology
Aged
Cell growth
Chemistry
RNA-Binding Proteins
Cell Biology
Middle Aged
medicine.disease
Phospholipid Hydroperoxide Glutathione Peroxidase
Prognosis
Raji cell
Lymphoma
Gene Expression Regulation, Neoplastic
Oxidative Stress
Cancer research
Female
Lymphoma, Large B-Cell, Diffuse
Diffuse large B-cell lymphoma
Oxidative stress
Subjects
Details
- ISSN :
- 15300307
- Volume :
- 101
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Laboratory investigation; a journal of technical methods and pathology
- Accession number :
- edsair.doi.dedup.....3b6896a70fbee1282732064b2afb9c16