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Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications
- Source :
- Annals of Nuclear Medicine
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Both prostate-specific membrane antigen (PSMA)- and somatostatin receptor (SSTR)-targeted positron emission tomography (PET)-based imaging agents for prostate carcinoma and neuroendocrine tumors, respectively, are seeing rapidly expanding use. In addition to diagnostic applications, both classes of radiotracers can be used to triage patients for theranostic endoradiotherapy. While interpreting PSMA- or SSTR-targeted PET/computed tomography (CT) scans, the reader has to be aware of certain pitfalls. Adding to the complexity of the interpretation of those imaging agents, both normal biodistribution, and also false-positive and -negative findings differ between PSMA- and SSTR-targeted PET radiotracers. Herein summarized under the umbrella term molecular imaging reporting and data systems (MI-RADS), two novel RADS classifications for PSMA- and SSTR-targeted PET imaging are described (PSMA- and SSTR-RADS). Notably, PSMA- and SSTR-RADS are structured in a reciprocal fashion, i.e., if the reader is familiar with one system, the other system can readily be applied, as well. In the present review, we will discuss the most common pitfalls on PSMA- and SSTR-targeted PET/CT, briefly introduce PSMA- and SSTR-RADS, and define a potential future role of the umbrella framework MI-RADS compared to other classification systems.
- Subjects :
- Diagnostic Imaging
Glutamate Carboxypeptidase II
Positron emission tomography
Biodistribution
Review Article
Neuroendocrine tumors
urologic and male genital diseases
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Neuroendocrine tumor
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Reporting and data systems
Receptors, Somatostatin
ddc:610
Radioactive Tracers
Membrane antigen
Radiotherapy
medicine.diagnostic_test
business.industry
Prostate-specific membrane antigen (PSMA)
Somatostatin receptor (SSTR)
General Medicine
Pet imaging
Theranostics
medicine.disease
Standardization
Research Design
030220 oncology & carcinogenesis
Antigens, Surface
Personalized medicine
Molecular imaging
Nuclear medicine
business
RADS
Subjects
Details
- ISSN :
- 18646433 and 09147187
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Annals of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....3b6003f000309864e4d843d086c1513b