Additional file 1 of Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression

Additional file 1: Fig S1. Presence of the C5aGFAP transgene increases C5a protein levels in brain. Fig S2. Locomotion and exploration during open field and object location memory training at 7 months. Fig S3. C5aR1 ablation reduces dystrophic neurites and reduces toxicity of amyloid plaques. Fig S4. Differential expression analysis show lack of sex-specific changes in gene expression in the Arctic mice. Fig S5. C5ar1 knockout in Arctic mice delays expression of characteristic AD and astrocyte-associated genes. Fig S6. Plaque accumulation is faster in hippocampus compared to cortex and is unaltered by C5a–C5aR1 modulation. Fig S7. Iba1 and CD68 not altered by C5a-C5aR1 modulation in Arctic mice, mirroring gene expression. Fig S8. Astrocyte polarization state in Arctic, ArcticC5aR1KO, and ArcticC5a+ mice.