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Increased number of subclones in lung squamous cell carcinoma elicits overexpression of immune related genes
- Source :
- Transl Lung Cancer Res
- Publication Year :
- 2020
- Publisher :
- AME Publishing Company, 2020.
-
Abstract
- BACKGROUND: Intratumoral heterogeneity is a cause of drug resistance that leads to treatment failure. We investigated the clinical implication of intratumoral heterogeneity inferred from the number of subclones that constituted a tumor and reasoned the etiology of subclonal expansion using RNA sequencing data. METHODS: Simple nucleotide variation, clinical data, copy number variation, and RNA-sequencing data from 481 The Cancer Genome Atlas-Lung Squamous Cell Carcinoma (TCGA-LUSC) cases were obtained from the Genomic Data Commons data portal. Clonal status was estimated from the allele frequency of the mutated genes using the SciClone package. RESULTS: The number of subclones that comprised a tumor had a positive correlation with the total mutations in a tumor (σ=0.477, P-value
- Subjects :
- 0301 basic medicine
business.industry
Clone (cell biology)
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immune system
Oncology
Downregulation and upregulation
030220 oncology & carcinogenesis
Gene expression
Cancer research
Medicine
Original Article
Copy-number variation
business
Lung cancer
Gene
Allele frequency
Subjects
Details
- ISSN :
- 22264477 and 22186751
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Translational Lung Cancer Research
- Accession number :
- edsair.doi.dedup.....3b5397abfbccfe95e0cbd50de97bce24
- Full Text :
- https://doi.org/10.21037/tlcr-19-589