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Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 6, p e66128 (2013)
- Publication Year :
- 2013
- Publisher :
- Public Library of Science, 2013.
-
Abstract
- Targeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. Therefore, development of novel tumor-specific ligands or pharmaceutical nanocarriers is highly desirable. In this study, we utilized phage display to identify a new targeting peptide, SP90, which specifically binds to breast cancer cells, and recognizes tumor tissues from breast cancer patients. We used confocal and electron microscopy to reveal that conjugation of SP90 with liposomes enables efficient delivery of drugs into cancer cells through endocytosis. Furthermore, in vivo fluorescent imaging demonstrated that SP90-conjugated quantum dots possess tumor-targeting properties. In tumor xenograft and orthotopic models, SP90-conjugated liposomal doxorubicin was found to improve the therapeutic index of the chemotherapeutic drug by selectively increasing its accumulation in tumors. We conclude that the targeting peptide SP90 has significant potential in improving the clinical benefits of chemotherapy in the treatment and the diagnosis of breast cancer.
- Subjects :
- Cancer Treatment
lcsh:Medicine
Mice, SCID
Pharmacology
Polyethylene Glycols
Mice
Drug Delivery Systems
Breast Tumors
Basic Cancer Research
Medicine
Nanotechnology
lcsh:Science
Multidisciplinary
Obstetrics and Gynecology
Oncology
Drug delivery
Female
Immunohistochemical Analysis
medicine.drug
Research Article
Biotechnology
Diagnostic Imaging
Drugs and Devices
Immunology
Materials Science
Breast Neoplasms
In Vitro Techniques
Biomaterials
Therapeutic index
Breast cancer
Cell Line, Tumor
Breast Cancer
Genetics
Animals
Humans
Doxorubicin
Biology
Nanomaterials
Cell Proliferation
Clinical Genetics
business.industry
lcsh:R
Personalized Medicine
Cancer
Cancers and Neoplasms
Human Genetics
Chemotherapy and Drug Treatment
medicine.disease
Targeted drug delivery
Cancer cell
Bionanotechnology
Immunologic Techniques
lcsh:Q
Nanocarriers
business
Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3b4487935adfbe2bf1268e750a1e5997