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Enhanced blood brain barrier permeability and glioblastoma cell targeting via thermoresponsive lipid nanoparticles
- Source :
- Nanoscale. 9(40)
- Publication Year :
- 2017
-
Abstract
- Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39–45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs. Thermoresponsive lipids were prepared by mixing liquid and solid fatty acids (0.1 : 1 to 2 : 1 ratio) and lipid mixtures exhibiting a solid–liquid phase transition at 39 °C were identified by plotting melting point against liquid contents. TLN were prepared by a hot melt encapsulation method using mono- or double-surfactant systems. TLN showed desirable size (
- Subjects :
- Materials science
Paclitaxel
Nanoparticle
Nanotechnology
02 engineering and technology
010402 general chemistry
Blood–brain barrier
01 natural sciences
Permeability
Drug Delivery Systems
Cell Line, Tumor
Zeta potential
medicine
Humans
General Materials Science
Viability assay
Particle Size
Cytotoxicity
Liposome
Temperature
021001 nanoscience & nanotechnology
Lipids
0104 chemical sciences
Drug Liberation
medicine.anatomical_structure
Permeability (electromagnetism)
Blood-Brain Barrier
Drug delivery
Biophysics
Nanoparticles
0210 nano-technology
Glioblastoma
Subjects
Details
- ISSN :
- 20403372
- Volume :
- 9
- Issue :
- 40
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....3b19d7761a50e041805af32113e53f9a