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Evaluation of antiangiogenic treatment effects on tumors' microcirculation by Bayesian physiological pharmacokinetic modeling and magnetic resonance imaging
- Source :
- Magnetic Resonance Imaging, Magnetic Resonance Imaging, Elsevier, 2006, 24 (8), pp.1059-67. ⟨10.1016/j.mri.2006.04.002⟩
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- International audience; A physiological pharmacokinetic (PBPK) model was used to estimate tumor microcirculation in nude mice with a grafted tumor. The kinetics of a rapid clearance blood pool agent, Vistarem, were investigated by dynamic MRI after bolus administration. Signal enhancements were recorded in arterial blood and in tumor tissue. To analyze these data, we developed a whole-body mathematical model of the agent's biodistribution using physiological parameters. The model included six compartments: arterial and venous plasma, tumor (split into capillaries and interstitium), and the rest of the body (also split into capillaries and interstitium). As an application, changes in tumor microcirculation parameters were evaluated in mice receiving either an antiangiogenic treatment (ZD4190) or a placebo. The analysis was performed in a Bayesian framework, and the model was fitted to experimental data using Markov Chain Monte Carlo techniques. Results showed a significant difference in tumor microcirculation between the two groups of mice when the microcirculation parameters are considered together. This whole-body physiological model enables to analyze jointly data in tumor tissue and in arterial blood. This leads to accurate estimates of microcirculation parameters and the evaluation of their uncertainty.
- Subjects :
- Male
Blood pool agent
Pathology
Contrast Media
030218 nuclear medicine & medical imaging
MESH: Magnetic Resonance Imaging
Mice
0302 clinical medicine
Heterocyclic Compounds
Neoplasms
MESH: Microcirculation
Medicine
MESH: Animals
MESH: Neoplasms
medicine.diagnostic_test
Neovascularization, Pathologic
Magnetic Resonance Imaging
MESH: Quinazolines
Dynamic contrast-enhanced MRI
Arterial blood
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Physiologically based pharmacokinetic modelling
Biodistribution
medicine.medical_specialty
MESH: Heterocyclic Compounds
MESH: Bayes Theorem
Biomedical Engineering
Biophysics
Mice, Nude
Microcirculation
03 medical and health sciences
Pharmacokinetics
MESH: Contrast Media
Organometallic Compounds
MESH: Mice, Nude
Animals
Radiology, Nuclear Medicine and imaging
MESH: Mice
[SDV.IB] Life Sciences [q-bio]/Bioengineering
business.industry
Magnetic resonance imaging
Bayes Theorem
MESH: Organometallic Compounds
Triazoles
Xenograft Model Antitumor Assays
MESH: Male
MESH: Triazoles
Quinazolines
business
MESH: Neovascularization, Pathologic
030217 neurology & neurosurgery
Neoplasm Transplantation
MESH: Neoplasm Transplantation
MESH: X
Subjects
Details
- Language :
- English
- ISSN :
- 0730725X
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Imaging, Magnetic Resonance Imaging, Elsevier, 2006, 24 (8), pp.1059-67. ⟨10.1016/j.mri.2006.04.002⟩
- Accession number :
- edsair.doi.dedup.....3b157d55163c0995f002f0c3398accf3