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Fcγ receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus

Authors :
Bevra H. Hahn
Eun Bong Lee
Betty P. Tsao
Chang Ho Shin
Yun Jong Lee
Kyeong Man Hong
Han Joo Baek
Seong Wook Kang
Yeong Wook Song
Eun Suk Chung
Source :
Rheumatology International. 21:222-226
Publication Year :
2002
Publisher :
Springer Science and Business Media LLC, 2002.

Abstract

Systemic lupus erythematosus (SLE) is characterized by the presence of various autoantibodies and the deposition of immune complex, which is cleared by Fcgamma receptors. Genotype analysis was done to investigate whether the FcgammaRIIIA-176F/V polymorphism is a risk factor for SLE in Koreans. We genotyped 145 Korean SLE patients and 75 control subjects for FcgammaRIIIA-176F/ V. After amplifying a 1.7-kb fragment containing the Fcgamma/RIIIA-176F/V polymorphic site using two FcgammaRIIIA gene-specific primers, we performed a nested polymerase chain reaction (PCR) for allele-specific genotyping at position 559 in FcgammaRIIIA. FcgammaRIIIA genotype or allele distribution was not significantly different between lupus patients and controls, and also between lupus nephritis patients and healthy controls. Neither creatinine clearance, 24 h urine proteinuria, number of American College of Rheumatology (ACR) criteria, nor the Systemic Lupus International Collaborating Clinics (SLICC)/ACR damage index was different according to the genotype. In conclusion, FcgammaRIIIA-176F/V polymorphism is not associated with SLE in Koreans.

Details

ISSN :
1437160X and 01728172
Volume :
21
Database :
OpenAIRE
Journal :
Rheumatology International
Accession number :
edsair.doi.dedup.....3b1522167bc51d752964bba5de44d123
Full Text :
https://doi.org/10.1007/s00296-001-0171-x