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An update of nanoparticle-based approaches for glioblastoma multiforme immunotherapy
- Source :
- Nanomedicine. 15:1861-1871
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Glioblastoma multiforme is a serious medical issue in the brain oncology field due to its aggressiveness and recurrence. Immunotherapy has emerged as a valid approach to counteract the growth and metastasization of glioblastoma multiforme. Among the different innovative approaches investigated, nanoparticles gain attention because of their versatility which is key in allowing precise targeting of brain tumors and increasing targeted drug delivery to the brain, thus minimizing adverse effects. This article reviews the progress made in this field over the past 2 years, focusing on nonspherical and biomimetic particles and on vectors for the delivery of nucleic acids. However, challenges still need to be addressed, considering the improvement of the particles passage across the blood–meningeal barrier and/or the blood–brain barrier, promoting the clinical translatability of these approaches.
- Subjects :
- brain
medicine.medical_treatment
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
Development
Bioinformatics
blood–brain barrier, brain, drug delivery, drug delivery, glioblastoma multiforme, immunotherapy, nanomedicine, nanoparticles
glioblastoma multiforme
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
General Materials Science
030304 developmental biology
0303 health sciences
Brain Neoplasms
business.industry
nanoparticle
Immunotherapy
blood-brain barrier
medicine.disease
nanomedicine
Targeted drug delivery
030220 oncology & carcinogenesis
drug delivery
Drug delivery
Nanoparticles
Nanomedicine
immunotherapy
Neoplasm Recurrence, Local
Glioblastoma
business
Oncology field
Subjects
Details
- ISSN :
- 17486963 and 17435889
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Nanomedicine
- Accession number :
- edsair.doi.dedup.....3b0cab488aab74b72cab447cb018edbe