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Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men
- Source :
- PLoS ONE, PLoS ONE, 2016, 11 (5), pp.e0154047. ⟨10.1371/journal.pone.0154047⟩, PLoS ONE, Vol 11, Iss 5, p e0154047 (2016), PLoS ONE, Public Library of Science, 2016, 11 (5), pp.e0154047. ⟨10.1371/journal.pone.0154047⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany and included in the analysis. Genome sequencing revealed that the isolates from the outbreak among MSM and from urethritis cases belonged to a clade within clonal complex 11. Proteome analysis showed they expressed nitrite reductase, enabling anaerobic growth as previously described for gonococci. Invasive isolates from MSM, but not urethritis isolates, further expressed functional human factor H binding protein associated with enhanced survival in a newly developed transgenic mouse model expressing human factor H, a complement regulatory protein. In conclusion, our data suggest that urethritis and outbreak isolates followed a joint adaptation route including adaption to the urogenital tract.
- Subjects :
- 0301 basic medicine
Male
Bacterial Diseases
Proteome
[SDV]Life Sciences [q-bio]
lcsh:Medicine
Gene Expression
Neisseria meningitidis, Serogroup C
Neisseria meningitidis
medicine.disease_cause
Pathology and Laboratory Medicine
Mouse models
Men who have sex with men
Disease Outbreaks
Mice
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Germany
Medicine and Health Sciences
Clade
lcsh:Science
Phylogeny
Multidisciplinary
Meningococcal disease
Genomics
Animal Models
3. Good health
Bacterial Pathogens
Chemistry
Infectious Diseases
Medical Microbiology
Complement Factor H
Host-Pathogen Interactions
Physical Sciences
France
Pathogens
Meningitis
Neisseria
Research Article
Nitrite Reductases
030106 microbiology
Mice, Transgenic
Biology
Meningitis, Meningococcal
Research and Analysis Methods
Genome sequencing
Microbiology
Evolution, Molecular
03 medical and health sciences
Model Organisms
Bacterial Proteins
medicine
Genetics
Animals
Humans
Urethritis
Mammalian genomics
ddc:610
Homosexuality, Male
Molecular Biology Techniques
Sequencing Techniques
Microbial Pathogens
Molecular Biology
Nitrites
Bacteria
lcsh:R
Sexual Preferences
Organisms
Chemical Compounds
Outbreak
Biology and Life Sciences
medicine.disease
Virology
Neisseria gonorrhoeae
Animal Genomics
People and Places
lcsh:Q
Population Groupings
Carrier Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, 2016, 11 (5), pp.e0154047. ⟨10.1371/journal.pone.0154047⟩, PLoS ONE, Vol 11, Iss 5, p e0154047 (2016), PLoS ONE, Public Library of Science, 2016, 11 (5), pp.e0154047. ⟨10.1371/journal.pone.0154047⟩
- Accession number :
- edsair.doi.dedup.....3b032ddc1908efa0f5e3b0a11ee2e43e