Proton-Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition in a Population-Based Study

There are no proven effective medical treatments to prevent calcium pyrophosphate crystal deposition (CPPD). Hypomagnesemia is a known CPPD risk factor. The present study was undertaken to carry out a real-world epidemiologic study on proton-pump inhibitor (PPI) use, which can cause hypomagnesemia, and CPPD risk.We conducted a time-stratified, propensity score (PS)-matched cohort study using the UK-based IQVIA Medical Research Data. We compared risk of incident CPPD among PPI users versus HWe identified 81,102 PPI and HIn this study using real-world data, incident use of PPIs was not associated with a higher risk of CPPD compared with incident H