Back to Search
Start Over
Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose
- Source :
- Biosens Bioelectron, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- We report on a wearable tear bioelectronic platform, integrating a microfluidic electrochemical detector into an eyeglasses nose-bridge pad, for non-invasive monitoring of key tear biomarkers. The alcohol-oxidase (AOx) biosensing fluidic system allowed real-time tear collection and direct alcohol measurements in stimulated tears, leading to the first wearable platform for tear alcohol monitoring. Placed outside the eye region this fully wearable tear-sensing platform addresses drawbacks of sensor systems involving direct contact with the eye as the contact lenses platform. Integrating the wireless electronic circuitry into the eyeglasses frame thus yielded a fully portable, convenient-to-use fashionable sensing device. The tear alcohol sensing concept was demonstrated for monitoring of alcohol intake in human subjects over multiple drinking courses, displaying good correlation to parallel BAC measurements. We also demonstrate for the first time the ability to monitor tear glucose outside the eye and the utility of wearable devices for monitoring vitamin nutrients in connection to enzymatic flow detector and rapid voltammetric scanning, respectively. These developments pave the way to build an effective eyeglasses system capable of chemical tear analysis.
- Subjects :
- Computer science
Biomedical Engineering
Biophysics
Wearable computer
Biosensing Techniques
02 engineering and technology
01 natural sciences
Article
Wearable Electronic Devices
Electrochemistry
GLICOSE
Humans
Alcohol measurement
Wearable technology
Monitoring, Physiologic
business.industry
010401 analytical chemistry
Non invasive
Electrochemical detector
Vitamins
General Medicine
021001 nanoscience & nanotechnology
eye diseases
0104 chemical sciences
Eyeglasses
Glucose
Alcohols
Tears
Alcohol intake
sense organs
0210 nano-technology
business
Biosensor
Biotechnology
Biomedical engineering
Subjects
Details
- ISSN :
- 09565663
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Biosensors and Bioelectronics
- Accession number :
- edsair.doi.dedup.....3ae88c1bda19877e36eb3d79961fc12d