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Metastatic lung adenocarcinoma- associated thrombotic microangiopathy in a renal transplant recipient
- Source :
- BMJ Case Rep
- Publication Year :
- 2018
-
Abstract
- Thrombotic microangiopathy (TMA) after renal transplantation can be a diagnostic challenge. TMA can occur with calcineurin inhibitors, allograft rejection, infection, mutations in complement regulatory proteins and autoimmunity. A 52-year-old male renal transplant recipient presented with extensive deep vein thrombosis. He developed transfusion-dependent microangiopathic haemolytic anaemia with thrombocytopenia. He did not respond calcineurin inhibitor cessation, eculizumab or plasma exchange. ADAMTS13 and complement levels were normal. Infection and autoimmune screens were negative. A diagnosis of metastatic adenocarcinoma was made on bone marrow biopsy. This represents a rare case of malignancy-associated TMA in a renal transplant recipient. Early diagnosis can facilitate the prompt initiation of chemotherapy which is the only treatment option.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Thrombotic microangiopathy
Lung Neoplasms
Adenocarcinoma of Lung
030204 cardiovascular system & hematology
030230 surgery
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Rare Disease
hemic and lymphatic diseases
Biopsy
medicine
Humans
Neoplasm Metastasis
medicine.diagnostic_test
business.industry
Thrombotic Microangiopathies
General Medicine
Eculizumab
Middle Aged
medicine.disease
Thrombosis
Kidney Transplantation
ADAMTS13
Transplantation
Calcineurin
medicine.anatomical_structure
Bone marrow
business
medicine.drug
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMJ case reports
- Accession number :
- edsair.doi.dedup.....3ae8231146ebd54ec14cb0c77c556e25