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Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA
- Source :
- Journal of Inorganic Biochemistry. 100:1314-1319
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The interaction with duplex DNA of a series of 12 previously synthesised ruthenium (II) complexes incorporating extended terpyridines or analogous ligands is reported. The interaction was investigated using absorption spectroscopy and also, when possible, luminescence spectroscopy. Binding parameters for the interactions were estimated using established models. It was found that binding affinities are relatively large and their magnitude is somewhat dependent on the metal centre attached to the ligand. Viscosity studies reveal that all the complexes interact with DNA through groove binding and not intercalation. The variation in binding affinities of these complexes is rationalised by a consideration of electrostatic and steric factors.
- Subjects :
- Steric effects
Molecular Structure
Absorption spectroscopy
Pyridines
Triazines
Chemistry
Ligand
Stereochemistry
Intercalation (chemistry)
chemistry.chemical_element
DNA
Biochemistry
Ruthenium
Inorganic Chemistry
Metal
chemistry.chemical_compound
Crystallography
visual_art
visual_art.visual_art_medium
Spectrophotometry, Ultraviolet
Spectroscopy
Triazine
Subjects
Details
- ISSN :
- 01620134
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Journal of Inorganic Biochemistry
- Accession number :
- edsair.doi.dedup.....3ae42be51b9579355fe6b7c57a594e28