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HIV Incidence and Risk Behaviours of People Who Inject Drugs in Bangkok, 1995-2012
- Source :
- EClinicalMedicine
- Publication Year :
- 2018
-
Abstract
- Background Three consecutive prospective studies were conducted among people who inject drugs (PWID) from May 1995 through June 2012 in Bangkok, Thailand. We examined data from these studies to evaluate HIV incidence and explore trends in risk behaviours. Methods We used data from a 1995–1998 cohort study, a 1999–2004 HIV vaccine trial, and a 2005–2012 HIV pre-exposure prophylaxis (PrEP) study to examine per-quarter trends in HIV incidence, using a restricted cubic spline function for time in a Poisson regression. We also examined temporal trends in HIV-associated risk behaviours. Findings HIV incidence declined from 5.7 per 100 person-years during the cohort study, to 2.7 per 100 person-years in the vaccine trial, to 0.7 per 100 person-years among PrEP study placebo recipients. Incidence peaked at 12.1 per 100 person-years in 1996 and declined to
- Subjects :
- Placebo
01 natural sciences
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Environmental health
medicine
030212 general & internal medicine
Poisson regression
0101 mathematics
Prospective cohort study
Tenofovir
business.industry
Incidence (epidemiology)
010102 general mathematics
Vaccine trial
Hiv incidence
virus diseases
HIV
General Medicine
medicine.disease
Thailand
HIV pre-exposure prophylaxis
symbols
business
People who inject drugs
Cohort study
Research Paper
Subjects
Details
- ISSN :
- 25895370
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- EClinicalMedicine
- Accession number :
- edsair.doi.dedup.....3ae0273a0379e641df62a2dc56a4fb9c