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Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice
- Source :
- Cell Reports, Vol 11, Iss 10, Pp 1529-1534 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- SummaryBoth caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose, and blood lipids. Severe CR, however, is unsustainable for most people; therefore, it is important to determine whether manipulating macronutrient ratios in ad-libitum-fed conditions can generate similar health outcomes. We present the results of a short-term (8 week) dietary manipulation on metabolic outcomes in mice. We compared three diets varying in protein to carbohydrate ratio under both CR and ad libitum conditions. Ad libitum LPHC diets delivered similar benefits to CR in terms of levels of insulin, glucose, lipids, and HOMA, despite increased energy intake. CR on LPHC diets did not provide additional benefits relative to ad libitum LPHC. We show that LPHC diets under ad-libitum-fed conditions generate the metabolic benefits of CR without a 40% reduction in total caloric intake.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Carbohydrate metabolism
General Biochemistry, Genetics and Molecular Biology
Article
Mice
Random Allocation
Nutritional Interventions
Internal medicine
medicine
Dietary Carbohydrates
Animals
Food science
lcsh:QH301-705.5
Caloric Restriction
2. Zero hunger
business.industry
Insulin
digestive, oral, and skin physiology
Caloric theory
Carbohydrate
Caloric intake
Mice, Inbred C57BL
Endocrinology
Dietary protein
Glucose
lcsh:Biology (General)
Dietary Proteins
business
Energy Intake
Subjects
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....3adf1370c23cdee4f9cbf5f43fd83fbb