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Nitidine chloride suppresses epithelial‐mesenchymal transition and stem cell‐like properties in glioblastoma by regulating JAK2/STAT3 signaling
- Source :
- Cancer Medicine, Vol 10, Iss 9, Pp 3113-3128 (2021), Cancer Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Glioblastoma is the most aggressive and common intracranial malignant tumor, and the prognosis is still poor after various treatments. Based on the poor prognosis of glioma, new drugs that suppress the rapid progression and aggressive growth of glioma are urgently needed. It has been reported that nitidine chloride (NC) can inhibit tumor growth and epithelial‐mesenchymal transition (EMT), and EMT is associated with cancer stem cell properties. The present study aimed to investigate the inhibitory effect of NC on the EMT process and stem cell‐like properties in glioma cells. The results showed that the migration and invasion abilities in U87 and LN18 glioma cells were significantly increased after the induction of EMT and these effects were inhibited by NC in a concentration‐dependent manner. NC treatment decreased the expression of EMT markers in glioma cells and self‐renewal capacity of glioma stem‐like cells. We demonstrated that these effects of NC were achieved via JAK2/STAT3 signaling. Taken together, these results indicate that NC inhibits the EMT process and glioma stem‐like properties via JAK2/STAT3 signaling pathway, suggesting that NC may be a potential anti‐glioma drug.<br />NC can inhibit the EMT process and glioma stem cell characteristics of glioma cells via modulation of JAK2/STAT3 signaling, suggesting that NC may be a potential anti‐glioma drug.
- Subjects :
- 0301 basic medicine
STAT3 Transcription Factor
Cancer Research
Epithelial-Mesenchymal Transition
Stat3 Signaling Pathway
gliosphere
Transforming Growth Factor beta1
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Cell Movement
Glioma
Cell Line, Tumor
medicine
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Invasiveness
Epithelial–mesenchymal transition
U87
neoplasms
nitidine chloride
RC254-282
Cell Proliferation
Original Research
Cancer Biology
Benzophenanthridines
epithelial‐mesenchymal transition
Transition (genetics)
Chemistry
Brain Neoplasms
JAK2/STAT3
apoptosis
glioblastoma
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Janus Kinase 2
medicine.disease
nervous system diseases
030104 developmental biology
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Neoplastic Stem Cells
Stem cell
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....3acb70bfed59a8b70d37c823e65eae82