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Intrahepatic Cholangiocarcinoma Progression: Prognostic Factors and Basic Mechanisms
- Source :
- Clinical Gastroenterology and Hepatology. 7:S68-S78
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- In this review, we will examine various molecular biomarkers for their potential to serve as independent prognostic factors for predicting survival outcome in postoperative patients with progressive intrahepatic cholangiocarcinoma. Specific rodent models of intrahepatic cholangiocarcinoma that mimic relevant cellular, molecular, and clinical features of the human disease are also described, not only in terms of their usefulness in identifying molecular pathways and mechanisms linked to cholangiocarcinoma development and progression, but also for their potential value as preclinical platforms for suggesting and testing novel molecular strategies for cholangiocarcinoma therapy. Last, recent studies aimed at addressing the role of desmoplastic stroma in promoting intrahepatic cholangiocarcinoma progression are highlighted in an effort to underline the potential value of targeting tumor stromal components together with that of cholangiocarcinoma cells as a novel therapeutic option for this devastating cancer.
- Subjects :
- Stromal cell
Rodentia
digestive system
Article
Survival outcome
Cholangiocarcinoma
Human disease
Stroma
medicine
Animals
Humans
neoplasms
Intrahepatic Cholangiocarcinoma
Hepatology
business.industry
Liver Neoplasms
Gastroenterology
Cancer
Prognosis
medicine.disease
Molecular biomarkers
digestive system diseases
Disease Models, Animal
Disease Progression
Cancer research
Hepatocyte growth factor
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15423565
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Clinical Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....3ac3003cea9bec76acead8e57f801d4d