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Effects of hemodilution on gastric regional perfusion and intramucosal pH
- Source :
- ResearcherID
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Abstract
- Acute normovolemic hemodilution (ANH) has been shown to be a cost-effective method of reducing allogenic blood transfusion during elective surgery. ANH has been implicated with impaired oxygenation in isolated canine gastric flaps. The present study was designed to investigate the effects of ANH on gastric mucosal oxygenation using a model closely imitating the clinical situation. Sixteen splenectomized anesthetized beagles were isovolemically hemodiluted to a hematocrit of 20 +/- 1% (6% hydroxyethyl starch; mol wt 200,000; substitution ratio 0.45-0.55). Blood volume (indocyanine green), cardiorespiratory parameters, gastric intramucosal pH (pHi), and gastric regional blood flow (radioactive microspheres; 15 microns) were measured before and after ANH. Results: blood volume was unchanged (87 +/- 8 ml/kg before and 88 +/- 7 ml/kg after ANH). Median total gastric mucosal blood flow at baseline was 0.51 +/- 0.35 ml.min-1.g-1 and did not change significantly upon ANH. The mean pHi was 7.29 +/- 0.05 before and 7.28 +/- 0.05 after hemodilution. There was a homogenization of blood flow distribution in gastric mucosa. Severe hemodilution to a hematocrit of 20% does not impair gastric mucosal oxygenation and poses no risk to gastric mucosal integrity.
- Subjects :
- Male
Blood transfusion
Physiology
medicine.medical_treatment
Hemodynamics
Blood volume
Hydroxyethyl starch
Hematocrit
Dogs
Physiology (medical)
Gastric mucosa
medicine
Animals
Hemodilution
medicine.diagnostic_test
business.industry
Respiration
Stomach
Blood flow
Hydrogen-Ion Concentration
medicine.anatomical_structure
Gastric Mucosa
Regional Blood Flow
Anesthesia
Female
Cardiology and Cardiovascular Medicine
business
Hydrogen
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.doi.dedup.....3aa997b0962bde495a6f7ac35e31b4e5