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Epoxy Resin Monomers with Reduced Skin Sensitizing Potency
- Source :
- Articles
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- Epoxy resin monomers, including diglycidyl ethers of bisphenol A and F (DGEBA and DGEBF), are extensively used as building blocks for thermosetting polymers. However, they are known to cause widespread contact allergy. This research describes a number of alternative epoxy resin monomers, designed with the aim of reducing the skin sensitizing potency whilst maintaining the ability to form thermosetting polymers. The compounds were designed, synthesized, assessed for skin sensitizing potency using the in vivo murine local lymph node assay, and tested for technical applicability using thermogravimetric analysis and differential scanning calorimetry. All the novel epoxy resin monomers had decreased skin sensitization potencies compared to DGEBA and DGEBF. With respect to EC3 values, which is the estimated concentration of a substance required to induce a 3-fold increase in sensitization compared to a control, the best of the new monomers had a value approximately 2.5 times higher than those of DGEBA and DGEBF. The diepoxides were reacted with triethylenetetramine and four out of the six novel monomers gave polymers with a thermal stability comparable to that obtained with DGEBA and DGEBF. The new epoxy resin monomers have the potential to replace DGEBA and DGEBF, leading to a decreased incidence of contact allergy due to epoxy resins, decreased healthcare costs, and an increased quality of life for those handling thermosetting materials.
- Subjects :
- Bisphenol A
Thermosetting polymer
Calorimetry
Toxicology
Mice
chemistry.chemical_compound
Toxicity Tests
Animals
Organic chemistry
skin sensitization
Thermal stability
Skin Tests
chemistry.chemical_classification
Molecular Structure
Epoxy resins
Epoxy Resins
Local lymph node assay
General Medicine
Epoxy
Polymer
Local Lymph Node Assay
Monomer
chemistry
Triethylenetetramine
polymerization
visual_art
Thermogravimetry
Mice, Inbred CBA
visual_art.visual_art_medium
Female
Lymph Nodes
Environmental Health
epoxy resin monomers
chemical reactivity
Subjects
Details
- ISSN :
- 15205010 and 0893228X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Chemical Research in Toxicology
- Accession number :
- edsair.doi.dedup.....3aa0d6e7a66ba62c6b2567b05dd464ad