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The role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes
- Source :
- Revista Brasileira de Hematologia e Hemoterapia v.37 n.4 2015, Revista brasileira de hematologia e hemoterapia, Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC), instacron:ABHHTC, Revista Brasileira de Hematologia e Hemoterapia, Revista Brasileira de Hematologia e Hemoterapia, Volume: 37, Issue: 4, Pages: 252-258, Published: AUG 2015, Revista Brasileira de Hematologia e Hemoterapia, Vol 37, Iss 4, Pp 252-258 (2015)
- Publication Year :
- 2015
- Publisher :
- Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2015.
-
Abstract
- Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are the only therapeutic option in approximately 40% of cases. The most serious side effect of regular blood transfusion is iron overload.Currently, cardiovascular magnetic resonance using T2 is routinely used to identify patients with myocardial iron overload and to guide chelation therapy, tailored to prevent iron toxicity in the heart. This is a major validated non-invasive measure of myocardial iron overloading and is superior to surrogates such as serum ferritin, liver iron, ventricular ejection fraction and tissue Doppler parameters.The indication for iron chelation therapy in myelodysplastic syndrome patients is currently controversial. However, cardiovascular magnetic resonance may offer an excellent non-invasive, diagnostic tool for iron overload assessment in myelodysplastic syndromes. Further studies are needed to establish the precise indications of chelation therapy and the clinical implications of this treatment on survival in myelodysplastic syndromes.
- Subjects :
- Ineffective erythropoiesis
medicine.medical_specialty
Pathology
Blood transfusion
Anemia
Magnetic
medicine.medical_treatment
Myelodysplastic syndromes
Review Article
medicine.disease_cause
Gastroenterology
Internal medicine
Medicine
Iron overload
Chelation therapy
medicine.diagnostic_test
lcsh:RC633-647.5
business.industry
Magnetic resonance imaging
lcsh:Diseases of the blood and blood-forming organs
Hematology
medicine.disease
medicine.anatomical_structure
Dysplasia
Bone marrow
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Revista Brasileira de Hematologia e Hemoterapia v.37 n.4 2015, Revista brasileira de hematologia e hemoterapia, Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC), instacron:ABHHTC, Revista Brasileira de Hematologia e Hemoterapia, Revista Brasileira de Hematologia e Hemoterapia, Volume: 37, Issue: 4, Pages: 252-258, Published: AUG 2015, Revista Brasileira de Hematologia e Hemoterapia, Vol 37, Iss 4, Pp 252-258 (2015)
- Accession number :
- edsair.doi.dedup.....3a9d2ae3fa8745fc87545d9eb2792a40