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Resveratrol Improves Heart Function by Moderating Inflammatory Processes in Patients with Systolic Heart Failure
- Source :
- Antioxidants, Vol 9, Iss 1108, p 1108 (2020), Antioxidants, Volume 9, Issue 11
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The effects of resveratrol (RES) in heart failure have already been evaluated in animal models<br />however, in human clinical trials, they have not been confirmed yet. The aim of this study was to assess the effects of resveratrol treatment in systolic heart failure patients (heart failure with reduced ejection fraction or HFrEF). In this human clinical trial, 60 outpatients with NYHA (New York Heart Association) class II-III HFrEF were enrolled and randomized into two groups: receiving either 100-mg resveratrol daily or placebo for three months. At the beginning and at the end of the study echocardiography, a six-minute walk test, spirometry, quality of life questionnaire, lab test and RNA profile analysis were performed. The systolic and diastolic left ventricular function, as well as the global longitudinal strain, were improved significantly in the resveratrol-treated group (RES). Exercise capacity, ventilation parameters and quality of life also improved significantly in the RES group. In parallel, the cardiac biomarker levels (N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3) decreased in the treated group. The level of inflammatory cytokines decreased significantly after RES supplementation, as a consequence of the decreased expression level of leucocyte electron transport chain proteins. The main findings of our trial are that RES treatment added to the standard heart failure therapy improved heart function and the clinical condition by moderating the inflammatory processes in patients with HFrEF.
- Subjects :
- 0301 basic medicine
Spirometry
medicine.medical_specialty
endocrine system diseases
Physiology
Clinical Biochemistry
Diastole
heart failure
030204 cardiovascular system & hematology
Resveratrol
resveratrol
Placebo
Biochemistry
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
oxidative stress
echocardiography
skin and connective tissue diseases
Molecular Biology
Ejection fraction
medicine.diagnostic_test
business.industry
organic chemicals
lcsh:RM1-950
food and beverages
Cell Biology
Brain natriuretic peptide
medicine.disease
Clinical trial
030104 developmental biology
lcsh:Therapeutics. Pharmacology
chemistry
inflammation
Heart failure
Cardiology
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- Language :
- English
- ISSN :
- 20763921
- Volume :
- 9
- Issue :
- 1108
- Database :
- OpenAIRE
- Journal :
- Antioxidants
- Accession number :
- edsair.doi.dedup.....3a9b95955c053b6ed5ae21ef63df4563