Bilateral optic disk swelling plus

A 64-year-old woman presented with bilateral optic neuropathy leading to a diagnosis of Sjogren syndrome. She improved with high-dose corticosteroids and oral azathioprine and was subsequently found to have asymptomatic bilateral iridocyclitis. Although central nervous system manifestations of Sjogren syndrome are documented in the literature, they are not widely recognized in clinical practice. Associated optic neuritis often mimics demyelinating disease such as multiple sclerosis. Treatment of CNS disease related to Sjogren syndrome is highly controversial. Uveitis is an uncommon finding associated with Sjogren syndrome.