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Efficient Surveillance of Plasmodium knowlesi Genetic Subpopulations, Malaysian Borneo, 2000-2018
- Source :
- Emerging Infectious Diseases, Emerging Infectious Diseases, Vol 26, Iss 7, Pp 1392-1398 (2020)
- Publication Year :
- 2020
-
Abstract
- Population genetic analysis revealed that Plasmodium knowlesi infections in Malaysian Borneo are caused by 2 divergent parasites associated with long-tailed (cluster 1) and pig-tailed (cluster 2) macaques. Because the transmission ecology is likely to differ for each macaque species, we developed a simple genotyping PCR to efficiently distinguish between and survey the 2 parasite subpopulations. This assay confirmed differences in the relative proportions in areas of Kapit division of Sarawak state, consistent with multilocus microsatellite analyses. Analyses of 1,204 human infections at Kapit Hospital showed that cluster 1 caused approximately two thirds of cases with no significant temporal changes from 2000 to 2018. We observed an apparent increase in overall numbers in the most recent 2 years studied, driven mainly by increased cluster 1 parasite infections. Continued monitoring of the frequency of different parasite subpopulations and correlation with environmental alterations are necessary to determine whether the epidemiology will change substantially.
- Subjects :
- Microbiology (medical)
Epidemiology
030231 tropical medicine
Population
vector-borne infections
malaria
lcsh:Medicine
parasitic diseases
parasites
Disease cluster
Macaque
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
Borneo
biology.animal
Anopheles
Parasite hosting
lcsh:RC109-216
Plasmodium knowlesi
030212 general & internal medicine
education
Genotyping
mosquitoes
education.field_of_study
biology
Malaysian Borneo
Research
lcsh:R
Malaysia
DNA, Protozoan
zoonosis
biology.organism_classification
Infectious Diseases
Genetics, Population
Evolutionary biology
surveillance
Microsatellite
Efficient Surveillance of Plasmodium knowlesi Genetic Subpopulations, Malaysian Borneo, 2000–2018
Subjects
Details
- ISSN :
- 10806059 and 10806040
- Volume :
- 26
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Emerging infectious diseases
- Accession number :
- edsair.doi.dedup.....3a80fccc974257dc65dd4ac86087cd04