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Optogenetics - Bringing light into the darkness of mammalian signal transduction
- Source :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:280-292
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Cells receive many different environmental clues to which they must adapt accordingly. Therefore, a complex signal transduction network has evolved. Cellular signal transduction is a highly dynamic process, in which the specific outcome is a result of the exact spatial and temporal resolution of single sub-events. While conventional techniques, like chemical inducer systems, have led to a sound understanding of the architecture of signal transduction pathways, the spatiotemporal aspects were often impossible to resolve. Optogenetics, based on genetically encoded light-responsive proteins, has the potential to revolutionize manipulation of signal transduction processes. Light can be easily applied with highest precision and minimal invasiveness. This review focuses on examples of optogenetic systems which were generated and applied to manipulate non-neuronal mammalian signaling processes at various stages of signal transduction, from cell membrane through cytoplasm to nucleus. Further, the future of optogenetic signaling will be discussed.
- Subjects :
- Mammals
0301 basic medicine
UVR8
Light
Membrane Proteins
Cell Biology
Optogenetics
Biology
Cellular signal transduction
Cell biology
Protein–protein interaction
03 medical and health sciences
Synthetic biology
030104 developmental biology
0302 clinical medicine
Animals
Humans
Signal transduction
Molecular Biology
030217 neurology & neurosurgery
PI3K/AKT/mTOR pathway
Signal Transduction
G protein-coupled receptor
Subjects
Details
- ISSN :
- 01674889
- Volume :
- 1864
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Accession number :
- edsair.doi.dedup.....3a803f109a15f980fc8b1aeba7f71c6e