Back to Search
Start Over
Role of intravital imaging in nanomedicine-assisted anti-cancer therapy
- Source :
- Current opinion in biotechnology. 69
- Publication Year :
- 2020
-
Abstract
- Although nanomedicines have provided promising anti-tumor effects in cancer animal models, their clinical success remains limited. One of the most significant barriers in the clinical translation of nanomedicines is that they consist of multiple components, each of which may have different toxicities and therapeutic effects. Intravital imaging provides high spatial and temporal resolution for visualizing nanomedicine-mediated interactions between immune cells and tumor cells in real-time. Intravital imaging can facilitate the in vivo evaluation of the properties and effects of nanomedicines, such as their ability to cross the tumor vasculature, specifically eliminate the cancer cells, and modulate the immune cells found in the tumor microenvironment (TME). Thus, intravital imaging can provide direct evidence of nanomedicine's intravital behavior to better understand mechanism and accelerate clinical translation. In this review, we summarize several applications and latest advances in intravital imaging in nanomedicine-assisted anti-cancer therapy and discuss future perspectives in the field.
- Subjects :
- 0106 biological sciences
Intravital Microscopy
Biomedical Engineering
Bioengineering
01 natural sciences
03 medical and health sciences
Immune system
In vivo
010608 biotechnology
Neoplasms
Tumor Microenvironment
Medicine
Animals
030304 developmental biology
0303 health sciences
Tumor microenvironment
business.industry
Mechanism (biology)
Cancer
Intravital Imaging
medicine.disease
Nanomedicine
Cancer cell
Immunotherapy
business
Neuroscience
Biotechnology
Subjects
Details
- ISSN :
- 18790429
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Current opinion in biotechnology
- Accession number :
- edsair.doi.dedup.....3a7edbb364f31e40bdd0096d3a9b8a90