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Pregnancy outcome in women with transfused beta-thalassemia in France

Authors :
Stanislas Nimubona
Giovanna Cannas
Jean-Antoine Ribeil
Isabelle Thuret
Sabine Jardel
Raoul Herbrecht
Frédéric Galactéros
Florence Lachenal
Marie-José Lucchini
Emilie Virot
Arnaud Hot
François Lionnet
Julie Machin
Source :
Annals of Hematology. 101:289-296
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Because of chronic anemia, hypogonadotropic hypogonadism, and iron chelation, pregnancy in homozygous and heterozygous compound beta-thalassemia patients stays a challenge. Pregnancies of transfused beta-thalassemia women registered in the French National Registry, conducted between 1995 and 2015, are described. These pregnancies were compared with pregnancies in healthy women and to data previously published in the literature. Fifty-six pregnancies of 37 women were studied. There were 5 twin pregnancies. Assisted reproductive technologies (ART) were used in 9 pregnancies. Median term at delivery was 39 amenorrhea weeks, and median weight at birth was 2780 g. Cesarean section was performed in 53.6% of the pregnancies. There were 6 thromboembolic events, 6 serious infections, 6 pregnancy-induced hypertensions (PIH), 6 intrauterine growth retardations (IUGR), 5 severe hemorrhages, 4 gestational diabetes, 3 alloimmunizations, 2 heart diseases, and 1 pre-eclampsia. There were 5 infections and 4 osteoporosis in the first year of post-partum. ART and cesarean sections were more often used in the beta-thalassemia group, compared to control subjects. Thromboembolic events, PIH, hemorrhage at delivery, and IUGR were more frequent in the beta-thalassemia group. Time to delivery was not different, but infant weight at birth was significantly smaller in the beta-thalassemia group. In the post-partum period, global maternal complications were more frequent in the beta-thalassemia group. Pregnancy in transfused beta-thalassemia women is safe with rare obstetrical and fetal complications. Cesarean section remains often chosen, and infant weight at birth remains smaller than that in the general population, despite delivery at full term.

Details

ISSN :
14320584 and 09395555
Volume :
101
Database :
OpenAIRE
Journal :
Annals of Hematology
Accession number :
edsair.doi.dedup.....3a7cd3f15aa31b094c5dd6dd4df40bc8
Full Text :
https://doi.org/10.1007/s00277-021-04697-4