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Pregnancy outcome in women with transfused beta-thalassemia in France
- Source :
- Annals of Hematology. 101:289-296
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Because of chronic anemia, hypogonadotropic hypogonadism, and iron chelation, pregnancy in homozygous and heterozygous compound beta-thalassemia patients stays a challenge. Pregnancies of transfused beta-thalassemia women registered in the French National Registry, conducted between 1995 and 2015, are described. These pregnancies were compared with pregnancies in healthy women and to data previously published in the literature. Fifty-six pregnancies of 37 women were studied. There were 5 twin pregnancies. Assisted reproductive technologies (ART) were used in 9 pregnancies. Median term at delivery was 39 amenorrhea weeks, and median weight at birth was 2780 g. Cesarean section was performed in 53.6% of the pregnancies. There were 6 thromboembolic events, 6 serious infections, 6 pregnancy-induced hypertensions (PIH), 6 intrauterine growth retardations (IUGR), 5 severe hemorrhages, 4 gestational diabetes, 3 alloimmunizations, 2 heart diseases, and 1 pre-eclampsia. There were 5 infections and 4 osteoporosis in the first year of post-partum. ART and cesarean sections were more often used in the beta-thalassemia group, compared to control subjects. Thromboembolic events, PIH, hemorrhage at delivery, and IUGR were more frequent in the beta-thalassemia group. Time to delivery was not different, but infant weight at birth was significantly smaller in the beta-thalassemia group. In the post-partum period, global maternal complications were more frequent in the beta-thalassemia group. Pregnancy in transfused beta-thalassemia women is safe with rare obstetrical and fetal complications. Cesarean section remains often chosen, and infant weight at birth remains smaller than that in the general population, despite delivery at full term.
- Subjects :
- Adult
medicine.medical_specialty
Population
Reproductive technology
Pregnancy
Humans
Medicine
education
Retrospective Studies
Full Term
education.field_of_study
Fetal Growth Retardation
Cesarean Section
business.industry
Obstetrics
Pregnancy Complications, Hematologic
beta-Thalassemia
Infant, Newborn
Pregnancy Outcome
Beta thalassemia
Hematology
General Medicine
medicine.disease
Gestational diabetes
Cross-Sectional Studies
Hemoglobinopathy
Female
Amenorrhea
France
medicine.symptom
Erythrocyte Transfusion
business
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....3a7cd3f15aa31b094c5dd6dd4df40bc8
- Full Text :
- https://doi.org/10.1007/s00277-021-04697-4