Back to Search
Start Over
Renal cell carcinoma marker (RCC-Ma) is specific for cutaneous metastasis of renal cell carcinoma
- Source :
- Journal of Cutaneous Pathology. 34:381-385
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Renal cell carcinoma marker (RCC-Ma) is a monoclonal antibody against a normal renal proximal tubule antigen. RCC-Ma expression is relatively specific for primary clear cell renal cell carcinoma. Its expression in cutaneous metastasis of renal cell carcinoma (MRCC) and other cutaneous clear cell lesions has not been studied.One hundred and thirty-seven cutaneous clear cell lesions including eight xanthomas, 32 xanthelasmas, 25 xanthogranulomas, seven balloon cell nevi, six clear cell hidradenomas, 29 sebaceous adenomas, six sebaceous epitheliomas, eight sebaceous carcinomas, and 16 MRCC were examined using immunohistochemistry for the expression of RCC-Ma.RCC-Ma was expressed in 10 of 16 (62.5%) MRCC, all with greater than 20% of cell labeling. Of these, 4 of 10 (40%) labeled with a membranous pattern and 6 of 10 (60%) labeled with both a membranous and a cytoplasmic pattern. RCC expression was not seen in any of the other clear cell lesions (p0.001). Furthermore, lack of expression in each of the other diagnostic groups was significant when each group was compared with the MRCCs (p0.01 at least for each group).Our study demonstrates that RCC may be a valuable component of a panel of immunohistochemical markers when evaluating cutaneous clear cell lesions.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Skin Neoplasms
Histology
Adolescent
Hidradenoma
Dermatology
urologic and male genital diseases
Pathology and Forensic Medicine
Diagnosis, Differential
Renal cell carcinoma
Biomarkers, Tumor
medicine
Carcinoma
Humans
Child
Carcinoma, Renal Cell
Aged
Aged, 80 and over
business.industry
Antibodies, Monoclonal
Infant
Middle Aged
medicine.disease
Immunohistochemistry
Kidney Neoplasms
Clear cell renal cell carcinoma
Child, Preschool
Monoclonal
business
Clear cell
Kidney disease
Subjects
Details
- ISSN :
- 16000560 and 03036987
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Cutaneous Pathology
- Accession number :
- edsair.doi.dedup.....3a57fc658c4c15cc5051ad600501af91