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Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
- Source :
- Dev. Dyn. 236, 282-289 (2007)
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- The Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP-J kappa, Notch1, and Notch2 conditional knockout mice. Disruption of the Notch pathway by inactivating RBP-J kappa in the melanocyte lineage using Tyr::Cre mice led to a severe coat color dilution. Similarly, hair graying was observed when Notch1 and/or Notch2 receptors were ablated in melanocytes. This phenotype was proportional to the number of floxed Notch alleles, with the most pronounced effect seen in Tyr::Cre/degrees; Notch1(flox/flox); Notch2(flox/flox) mice. Deletion of Notch1 and/or Notch2 in melanoblasts did not induce a congenital defect. The number of Dct-expressing cells at embryonic stages was not affected, but melanocytes located within the hair matrix progressively disappeared during the first regeneration of the hair follicle. In contrast, non-follicular melanocytes and pigmentation in the dermis and in the choroid were not affected. We suggest that both Notch1 and Notch2 receptors contribute to the maintenance of melanoblasts and melanocyte stem cells, and are essential for proper hair pigmentation.
- Subjects :
- endocrine system
medicine.medical_specialty
Genotype
Notch signaling pathway
Mice, Transgenic
Melanocyte
Cell fate determination
Biology
Mice
Dermis
Internal medicine
Conditional gene knockout
medicine
Animals
Cell Lineage
Receptor, Notch2
Receptor, Notch1
Hair Color
Alleles
In Situ Hybridization
Mice, Knockout
Embryo, Mammalian
Hair follicle
Embryonic stem cell
Cell biology
Intramolecular Oxidoreductases
Phenotype
medicine.anatomical_structure
Endocrinology
melanocyte
notch
pigmentation
coat colory
transgenic
hair graying
stem cell
Melanocytes
sense organs
Stem cell
Hair Follicle
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 10970177 and 10588388
- Volume :
- 236
- Database :
- OpenAIRE
- Journal :
- Developmental Dynamics
- Accession number :
- edsair.doi.dedup.....3a57cc12d450505d18fca3b167831776