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Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors
- Source :
- Cell hostmicrobe. 25(2)
- Publication Year :
- 2018
-
Abstract
- Summary Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3–4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Milk microbiota composition and diversity were associated with maternal factors (BMI, parity, and mode of delivery), breastfeeding practices, and other milk components in a sex-specific manner. Causal modeling identified mode of breastfeeding as a key determinant of milk microbiota composition. Specifically, providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria. Further, these data support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota. Collectively, these results identify features and determinants of human milk microbiota composition, with potential implications for infant health and development.
- Subjects :
- Adult
DNA, Bacterial
Male
Firmicutes
Maternal Health
Breastfeeding
Physiology
Infant health
Gut flora
digestive system
Microbiology
Cohort Studies
03 medical and health sciences
fluids and secretions
0302 clinical medicine
Sex Factors
Virology
Proteobacteria
Humans
Microbiome
Longitudinal Studies
030304 developmental biology
2. Zero hunger
0303 health sciences
biology
Milk, Human
food and beverages
Infant
biology.organism_classification
Early life
stomatognathic diseases
Breast Feeding
Parasitology
Composition (visual arts)
Female
Bifidobacterium
030217 neurology & neurosurgery
Maternal Age
Subjects
Details
- ISSN :
- 19346069
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell hostmicrobe
- Accession number :
- edsair.doi.dedup.....3a4eba89f9df904dcee129d539e9bcfd