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cFLIP expression is altered in severe corticosteroid-resistant asthma
- Source :
- Genomics Data, Vol 2, Iss C, Pp 99-104 (2014), Genomics Data
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.
- Subjects :
- Gene isoform
lcsh:QH426-470
Microarray
Microarrays
Bioinformatics
Biochemistry
03 medical and health sciences
Exon
0302 clinical medicine
Genetics
skin and connective tissue diseases
Caspase
030304 developmental biology
0303 health sciences
Messenger RNA
biology
Alternative splicing
Regular Article
Asthma
3. Good health
lcsh:Genetics
Apoptosis
Cancer research
biology.protein
Molecular Medicine
sense organs
DNA microarray
030215 immunology
Biotechnology
Subjects
Details
- ISSN :
- 22135960
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Genomics Data
- Accession number :
- edsair.doi.dedup.....3a45d311362aa0de10de2ed823de5708