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In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies
- Source :
- Cellular and Molecular Life Sciences, Cellular and Molecular Life Sciences, Springer Verlag, 2014, 71 (20), pp.4007-4026. ⟨10.1007/s00018-014-1675-3⟩, Cellular and Molecular Life Sciences, 2014, 71 (20), pp.4007-4026. ⟨10.1007/s00018-014-1675-3⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; Although our knowledge of the biology of brain tumors has increased tremendously over the past decade, progress in treatment of these deadly diseases remains modest. Developing in vivo models that faithfully mirror human diseases is essential for the validation of new therapeutic approaches. Genetically engineered mouse models (GEMMs) provide elaborate temporally and genetically controlled systems to investigate the cellular origins of brain tumors and gene function in tumorigenesis. Furthermore, they can prove to be valuable tools for testing targeted therapies. In this review, we discuss GEMMs of brain tumors, focusing on gliomas and medulloblastomas. We describe how they provide critical insights into the molecular and cellular events involved in the initiation and maintenance of brain tumors, and illustrate their use in preclinical drug testing.
- Subjects :
- MESH: Receptor, EphB2
Receptor, EphB2
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SDV.CAN]Life Sciences [q-bio]/Cancer
Review
Biology
medicine.disease_cause
Mouse models
Cell of origin
Proto-Oncogene Proteins c-myc
Cellular and Molecular Neuroscience
[SDV.CAN] Life Sciences [q-bio]/Cancer
In vivo
Glioma
medicine
MESH: Proto-Oncogene Proteins c-myc
Animals
Hedgehog Proteins
MESH: Animals
MESH: Tumor Suppressor Protein p53
Molecular Biology
Medulloblastoma
Pharmacology
Neural stem cells
Tumor biology
Brain Neoplasms
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Cell Biology
MESH: Hedgehog Proteins
medicine.disease
3. Good health
Wnt Proteins
MESH: Wnt Proteins
Disease Models, Animal
Genetically Engineered Mouse
Immunology
MESH: Brain Neoplasms
Molecular Medicine
MESH: Genetic Engineering
Tumor Suppressor Protein p53
MESH: Disease Models, Animal
Carcinogenesis
Genetic Engineering
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X and 14209071
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences, Cellular and Molecular Life Sciences, Springer Verlag, 2014, 71 (20), pp.4007-4026. ⟨10.1007/s00018-014-1675-3⟩, Cellular and Molecular Life Sciences, 2014, 71 (20), pp.4007-4026. ⟨10.1007/s00018-014-1675-3⟩
- Accession number :
- edsair.doi.dedup.....3a40be64c905dd64fb9d30a9c913fe5d