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Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans
- Source :
- Nutrition (Burbank, Los Angeles County, Calif.). 31(10)
- Publication Year :
- 2014
-
Abstract
- Objectives The aim of this study was to compare the ketogenic effect of the peroxisome proliferator-activated receptor-α stimulator, bezafibrate (BEZA), alone or in combination with medium-chain triacylglycerols (MCTs) in healthy adults. Methods Eighteen healthy adults completed the study: 10 were given a therapeutic dose of BEZA (400 mg/d) for 8 wk followed by a further 4 wk of BEZA (400 mg/d) plus MCT (60 g/d). Eight other participants were given MCT alone (60 g/d) for 4 wk. All participants underwent identical metabolic study days: (a) pretreatment (the control), and after (b) BEZA combined with MCT (BEZA+MCT) or (c) an equal dose of MCT only. On the metabolic study days, a standard breakfast and lunch were given and blood samples were taken hourly to measure plasma ketones, glucose, and fatty acids. Results The combination of BEZA+MCT increased ketones twofold during the metabolic study day. The addition of BEZA increased early ketogenic efficiency of MCT by 2.5-fold but did not result in higher peak or mean concentration of ketones during the metabolic study day. No other differences were seen in plasma metabolites or insulin during metabolic study days. On the final metabolic study day, MCT or BEZA+MCT had different effects on the plasma acetoacetate-to-β-hydroxybutyrate ratio compared with control. Conclusions BEZA mildly potentiated the ketogenic action of MCT but did not increase peak plasma ketone concentration or overall ketone production during the metabolic study day.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Ketone concentration
medicine.drug_class
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Fibrate
Acetoacetates
Therapeutic index
Internal medicine
medicine
Metabolic study
Humans
Triglycerides
Aged
Hypolipidemic Agents
Nutrition and Dietetics
Bezafibrate
3-Hydroxybutyric Acid
Chemistry
Insulin
Fatty Acids
Medium chain triacylglycerols
Ketones
Middle Aged
Healthy Volunteers
Peak plasma
Endocrinology
Drug Therapy, Combination
Female
medicine.drug
Subjects
Details
- ISSN :
- 18731244
- Volume :
- 31
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrition (Burbank, Los Angeles County, Calif.)
- Accession number :
- edsair.doi.dedup.....3a323a765830fe4696b0d0a8ab782f21