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Biomphalaria glabrata transcriptome: Identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES)
- Source :
- Developmental and Comparative Immunology
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Biomphalaria glabrata is the major intermediate snail host for Schistosoma mansoni, one of the important schistosomes infecting man. Much remains to be discovered concerning specific molecules mediating the defence events in these intermediate hosts, triggered by invading schistosomes. An expressed sequence tag (EST) gene discovery strategy known as ORESTES has been employed to identify transcripts that might be involved in snail–schistosome interactions in order to examine gene expression patterns in infected B. glabrata. Over 3930 ESTs were sequenced from cDNA libraries made from both schistosome-exposed and unexposed snails using different tissue types, producing a database of 1843 non-redundant clones. The non-redundant set has been assessed for gene ontology and KEGG pathway assignments. This approach has revealed a number of signalling, antioxidant and immune-related gene homologues that, based on current understanding of molluscan and other comparative systems, might play an important role in the molluscan defence response towards infection.
- Subjects :
- Transcription, Genetic
Molecular Sequence Data
Immunology
Biomphalaria
Molluscan defence
Gene Expression
Biomphalaria glabrata
Article
Host-Parasite Interactions
Transcriptome
03 medical and health sciences
Open Reading Frames
0302 clinical medicine
Expressed sequence tag
parasitic diseases
ORESTES
Animals
EST
Gene
030304 developmental biology
Genetics
Expressed Sequence Tags
0303 health sciences
Differential display
Genomic Library
biology
cDNA library
Reverse Transcriptase Polymerase Chain Reaction
fungi
Computational Biology
Schistosoma mansoni
biology.organism_classification
Molecular biology
3. Good health
Open reading frame
030217 neurology & neurosurgery
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 0145305X
- Volume :
- 31
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Developmental & Comparative Immunology
- Accession number :
- edsair.doi.dedup.....3a2f37d7a2450b736f4864d9018b22fb
- Full Text :
- https://doi.org/10.1016/j.dci.2006.11.004