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Effect of Platelet Activating Factor Antgaonist(CV-3988) on 6-keto-PGF1.ALPHA. and Thromoboxane B2 in Dogs with Experimental Endotoxin-Induced Shock
- Source :
- Journal of Veterinary Medical Science. 57:81-85
- Publication Year :
- 1995
- Publisher :
- Japanese Society of Veterinary Science, 1995.
-
Abstract
- The effect of CV-3988, a platelet activating factor antagonist, in the treatment of endotoxic shock was evaluated from the changes in plasma 6-keto-PGF1 alpha and thromboxane B2 concentrations. The animals consisted of 10 beagle dogs anesthetized with pentobarbital sodium and divided into a treatment group (n = 5) and a control group (n = 5). Endotoxic shock was experimentally induced in both groups by intravenous administration of endotoxin (lipopolysaccharide, 3 mg/kg). The treatment group was intravenously given 10 mg/kg of CV-3988 for 10 min from immediately after endotoxin. Mean aortic pressure, cardiac output and urine volume were remarkably decreased after the administration of endotoxin to both groups. These parameters were higher after the administration of CV-3988, in the treatment group than in the control group. Furthermore, the increase in plasma 6-keto-PGF1 alpha and thromboxane B2 concentrations was significantly inhibited. These results suggest the effectiveness of CV-3988 in the treatment of endotoxic shock.
- Subjects :
- medicine.medical_specialty
Pentobarbital
Cardiac output
Lipopolysaccharide
Sodium
chemistry.chemical_element
6-Ketoprostaglandin F1 alpha
Beagle
chemistry.chemical_compound
Dogs
Internal medicine
medicine
Animals
Dog Diseases
Platelet Activating Factor
General Veterinary
Chemistry
Hemodynamics
Mean Aortic Pressure
Phospholipid Ethers
Shock, Septic
Thromboxane B2
Endocrinology
Shock (circulatory)
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....3a2d0f7da783204b4b915a99da40dc36