Back to Search
Start Over
Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function
- Source :
- Metabolic Syndrome and Related Disorders. 16:406-415
- Publication Year :
- 2018
- Publisher :
- Mary Ann Liebert Inc, 2018.
-
Abstract
- The aims of this study were to 1. define the responses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, and peptide YY (PYY) to an oral meal and to intravenous L-arginine; and 2. examine correlation of enteroendocrine hormones with insulin secretion. We hypothesized a relationship between circulating incretin concentrations and insulin secretion.Subjects with normal glucose tolerance (NGT, n = 23), prediabetes (PDM, n = 17), or with type 2 diabetes (T2DM, n = 22) were studied twice, following a mixed test meal (470 kCal) (mixed meal tolerance test [MMTT]) or intravenous L-arginine (arginine maximal stimulation test [AST], 5 g). GLP-1 (total and active), PYY, GIP, glucagon, and β cell function were measured before and following each stimulus.Baseline enteroendocrine hormones differed across the glucose tolerance (GT) spectrum, T2DM generallyNGT and PDM. In response to MMTT, total and active GLP-1, GIP, glucagon, and PYY increased in all populations. The incremental area-under-the-curve (0-120 min) of analytes like total GLP-1 were often higher in T2DM compared with NGT and PDM (35-51%; P 0.05). At baseline glucose, L-arginine increased total and active GLP-1 and glucagon concentrations in all GT populations (all P 0.05). As expected, the MMTT and AST provoked differential glucose, insulin, and C-peptide responses across GT populations. Baseline or stimulated enteroendocrine hormone concentrations did not consistently correlate with either measure of β cell function.Both MMTT and AST resulted in insulin and enteroendocrine hormone responses across GT populations without consistent correlation between release of incretins and insulin, which is in line with other published research. If a defect is in the enteroendocrine/β cell axis, it is probably reduced response to rather than diminished secretion of enteroendocrine hormones.
- Subjects :
- Blood Glucose
0301 basic medicine
endocrine system
medicine.medical_specialty
β cell function
Time Factors
Arginine
Enteroendocrine Cells
Endocrinology, Diabetes and Metabolism
Incretin
030209 endocrinology & metabolism
Gastric Inhibitory Polypeptide
Type 2 diabetes
Mixed meal
Glucagon
Gastrointestinal Hormones
Prediabetic State
Eating
03 medical and health sciences
0302 clinical medicine
Glucagon-Like Peptide 1
Insulin-Secreting Cells
Internal medicine
Internal Medicine
medicine
Humans
Insulin
Peptide YY
Insulin secretion
business.industry
digestive, oral, and skin physiology
Correction
Postprandial Period
medicine.disease
United States
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
Administration, Intravenous
business
Biomarkers
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15578518 and 15404196
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Metabolic Syndrome and Related Disorders
- Accession number :
- edsair.doi.dedup.....39f74e5236fb2a728c410fb0ee5c15c8