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Drosophila Trachea as a Novel Model of COPD
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 12730, p 12730 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- COPD, a chronic obstructive pulmonary disease, is one of the leading causes of death worldwide. Clinical studies and research in rodent models demonstrated that failure of repair mechanisms to cope with increased ROS and inflammation in the lung leads to COPD. Despite this progress, the molecular mechanisms underlying the development of COPD remain poorly understood, resulting in a lack of effective treatments. Thus, an informative, simple model is highly valued and desired. Recently, the cigarette smoke-induced Drosophila COPD model showed a complex set of pathological phenotypes that resemble those seen in human COPD patients. The Drosophila trachea has been used as a premier model to reveal the mechanisms of tube morphogenesis. The association of these mechanisms to structural changes in COPD can be analyzed by using Drosophila trachea. Additionally, the timeline of structural damage, ROS, and inflammation can be studied in live organisms using fluorescently-tagged proteins. The related function of human COPD genes identified by GWAS can be screened using respective fly homologs. Finally, the Drosophila trachea can be used as a high-throughput drug screening platform to identify novel treatments for COPD. Therefore, Drosophila trachea is an excellent model that is complementary to rodent COPD models.
- Subjects :
- QH301-705.5
Inflammation
Genome-wide association study
trachea
Review
Biology
Bioinformatics
Catalysis
Inorganic Chemistry
medicine
COPD
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
Gene
QD1-999
Spectroscopy
Lung
model
Organic Chemistry
fungi
General Medicine
medicine.disease
Phenotype
Computer Science Applications
respiratory tract diseases
Chemistry
medicine.anatomical_structure
Drosophila
Tube morphogenesis
medicine.symptom
Function (biology)
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....39f6bda15cb632b01591c5eb9bcaa523