Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation

Background and Aims Aim of this study is to evaluate the effects of kidney or kidney-pancreas transplantation on haemostatic abnormalities in uremic type 1 diabetic patients. Materials and Methods This is a cross-sectional study involving 12 type 1 diabetic patients (T1DM), 30 uremic type 1 diabetic patients (U+T1DM), 27 uremic type 1 diabetic kidney-pancreas transplanted patients (KP), 12 uremic type 1 diabetic kidney-alone transplanted diabetic (KD) and 13 healthy controls (C). Platelets morphology, receptors and intracellular signalling, markers of hypercoagulability and natural anti-coagulants were evaluated. Results a) Platelets morphology: The U+T1DM group showed higher platelet size than all the other groups (p