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Vitamin A is a necessary factor for sympathetic- independent rhythmic activation of mitogen-activated protein kinase in the rat pineal gland
- Source :
- European Journal of Neuroscience, European Journal of Neuroscience, 2005, 21 (3), pp.798--802. ⟨10.1111/j.1460-9568.2005.03901.x⟩
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- The circadian clock in the suprachiasmatic nucleus (SCN) controls day-to-day physiology and behavior by sending timing messages to multiple peripheral oscillators. In the pineal gland, a major SCN target, circadian events are believed to be driven exclusively by the rhythmic release of norepinephrine from superior cervical ganglia (SCG) neurons relaying clock messages through a polysynaptic pathway. Here we show in rat an SCN-driven daily rhythm of pineal MAPK activation that is not dependent on the SCG and whose maintenance requires vitamin A as a blood-borne factor. This finding challenges the dogma that SCG-released norepinephrine is an exclusive mediator of SCN-pineal communication and allows the assumption that humoral mechanisms are involved in pineal integration of temporal messages.
- Subjects :
- endocrine system
Suprachiasmatic nucleus
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
General Neuroscience
Circadian clock
Biology
Neuroendocrinology
Pinealocyte
Pineal gland
Norepinephrine
medicine.anatomical_structure
nervous system
Light effects on circadian rhythm
medicine
sense organs
Circadian rhythm
Neuroscience
ComputingMilieux_MISCELLANEOUS
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 14609568 and 0953816X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- European Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....39e68f057b5c0e1ea4d48eb225d9a431