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Effect of HO-3089 PARP inhibitor on inflammatory response

Authors :
Krisztian Tanczos
M. Németh
A Mikor
K Kovacs
Tamas Leiner
Zsolt Molnár
Source :
Critical Care
Publication Year :
2011
Publisher :
Springer Science and Business Media LLC, 2011.

Abstract

The activation of poly-ADP-ribose-polymerase enzyme (PARP) plays an important role in the pathophysiology of sepsis [1]. In previous animal models, lipopolysaccharide-induced systemic inflammatory response was significantly reduced by the inhibition of PARP [2]. The aim of our study was to investigate the effect of PARP inhibition on systemic inflammation in a septic animal model.

Subjects

Subjects :
Veterinary medicine
business.industry
Poly ADP ribose polymerase
Inflammatory response
Pharmacology
Critical Care and Intensive Care Medicine
medicine.disease
Systemic inflammation
Pathophysiology
Sepsis
Animal model
Poster Presentation
PARP inhibitor
medicine
medicine.symptom
business

Details

ISSN :
13648535
Volume :
15
Database :
OpenAIRE
Journal :
Critical Care
Accession number :
edsair.doi.dedup.....39e0896dac8dfb8830a4ccbebf42cdd5
Full Text :
https://doi.org/10.1186/cc9672
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