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Retrospective analysis of HHV-8 viremia and cellular viral load in HIV-seropositive patients receiving interleukin 2 in combination with antiretroviral therapy
- Source :
- Scopus-Elsevier, ResearcherID
- Publication Year :
- 2002
- Publisher :
- AMER SOC HEMATOLOGY, 2002.
-
Abstract
- The combination of interleukin 2 (IL-2) and antiretroviral therapy (ART) represents an emerging strategy in the treatment of patients infected with HIV. Aside from its immunomodulatory role, however, IL-2 may induce replication of human herpesvirus 8 (HHV-8)/Kaposi sarcoma (KS)-associated herpesvirus. We retrospectively evaluated HHV-8 plasma viremia and cellular load, as well as anti-HHV-8 antibody titers, in sequential samples from 84 patients receiving ART alone or in combination with IL-2. At baseline, HHV-8 plasma viremia was present only in 2 HHV-8-seropositive patients in whom KS subsequently developed during or immediately after termination of IL-2 therapy. The level of viremia increased during follow-up and peaked at the time of the clinical manifestation of KS. Moreover, transient peaks of HHV-8 viremia were temporally associated with administration of IL-2. HHV-8 plasma viremia was never detected in the other 47 patients receiving IL-2 nor in 35 controls treated only with ART. Thus, IL-2 therapy seems safe in most patients infected with both HIV and HHV-8, except for those with detectable HHV-8 viremia, who may not be eligible for IL-2 treatment. (C) 2002 by The American Society of Hematology.
- Subjects :
- Male
treatment planning
viruses
serology
medicine.disease_cause
immunomodulation
Biochemistry
Aldesleukin
dose response
HIV Seropositivity
Medicine
Human herpesvirus 8
Sida
virus replication
biology
antiretrovirus agent
Human immunodeficiency virus
herpes
article
virus diseases
Hematology
Middle Aged
Viral Load
female
priority journal
Herpesvirus 8, Human
Combination
Drug Therapy, Combination
Viral disease
Viral load
Adult
Settore MED/17 - Malattie Infettive
Anti-HIV Agents
Immunology
Viremia
interleukin 2
Herpesviridae
Virus
virus antibody
Acquired immunodeficiency syndrome (AIDS)
Drug Therapy
Human immunodeficiency virus infection
follow up
Humans
controlled study
human
Herpesvirus 8
Aged
Retrospective Studies
business.industry
Cell Biology
virus load
medicine.disease
biology.organism_classification
Virology
major clinical study
treatment outcome
HIV-1
Interleukin-2
adult
male
viremia
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, ResearcherID
- Accession number :
- edsair.doi.dedup.....39dd5b2dd16f360044628244170cfb96