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Vertical transmission of SARS‐CoV‐2: A prospective cross‐sectional study from a tertiary center
- Source :
- Journal of Medical Virology
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The aim was to investigate the association of the delivery mode and vertical transmission of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) through the samples of vaginal secretions, placenta, cord blood, or amniotic fluid as well as the neonatal outcomes. This cross‐sectional study presents an analysis of prospectively gathered data collected at a single tertiary hospital. Sixty‐three pregnant women with confirmed coronavirus disease 2019 (COVID‐19) participated in the study. Vertical transmission of SARS‐CoV‐2 was analyzed with reverse transcriptase‐polymerase chain reaction (RT‐PCR) tests and blood tests for immunoglobulin G (IgG)–immunoglobulin M (IgM) antibodies. All patients were in the mild or moderate category for COVID‐19. Only one placental sample and two of the vaginal secretion samples were positive for SARS‐CoV‐2. Except for one, all positive samples were obtained from patients who gave birth by cesarean. All cord blood and amniotic fluid samples were negative for SARS‐CoV‐2. Two newborns were screened positive for COVID‐19 IgG–IgM within 24 h after delivery, but the RT‐PCR tests were negative. A positive RT‐PCR result was detected in a neof a mother whose placenta, cord blood, amniotic fluid, and vaginal secretions samples were negative. He died due to pulmonary hemorrhage on the 11th day of life. In conclusion, we demonstrated that SARS‐CoV‐2 can be detectable in the placenta or vaginal secretions of pregnant women. Detection of the virus in the placenta or vaginal secretions may not be associated with neonatal infection. Vaginal delivery may not increase the incidence of neonatal infection, and cesarean may not prevent vertical transmission. The decision regarding the mode of delivery should be based on obstetric indications and COVID‐19 severity.
- Subjects :
- Adult
Male
medicine.medical_specialty
Amniotic fluid
Adolescent
Placenta
Infant, Newborn, Diseases
SARS‐CoV‐2
neonatal outcome
Tertiary Care Centers
delivery mode
Young Adult
03 medical and health sciences
0302 clinical medicine
Pregnancy
COVID‐19
Virology
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Pregnancy Complications, Infectious
Research Articles
Cesarean Section
SARS-CoV-2
business.industry
Obstetrics
Vaginal delivery
Infant, Newborn
Pregnancy Outcome
COVID-19
Delivery mode
medicine.disease
Infectious Disease Transmission, Vertical
Neonatal infection
Cross-Sectional Studies
Infectious Diseases
medicine.anatomical_structure
Cord blood
Vagina
Female
vertical transmission
030211 gastroenterology & hepatology
business
Research Article
Subjects
Details
- ISSN :
- 10969071 and 01466615
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology
- Accession number :
- edsair.doi.dedup.....39d2ff46229667c01bc650cceb0f0d47